CAUTION: SCHEDULE E-1 DRUG. TO BE TAKEN UNDER MEDICAL SUPERVISION

DESCRIPTION

Cannaron^® is a natural Cannabis medicine for all neuro-degenerative diseases. It helps manage age-related ailments of the brain and the nervous system. It brings relief from wide spectrum of neuropathic conditions, nourishes the neural network, and improves mood and quality of life. A true lifesaver for patients with depression, it has the potential to stimulate, energize and uplift mood.

This medicine is FREE from chemicals, artificial flavors or sweeteners, sugar, starch, salt, gluten, soy, pesticides and heavy metals

BENEFITS

Neuro-degenerative diseases: Neuro-degenerative diseases like Alzheimer's, Parkinson's, MS, Muscle spasms and othersare caused due to inflammation. Inflammation causes increasedproduction of beta-amyloid molecules (a sticky type of proteins), which forms amyloid plaques to accumulate between the neurons and creates damage to neurons in brain. THC is found to promote the removal of toxic clumps of amyloid beta protein in the brain and thus protect neurons (1).

Chronic pain: THC (one of CB1 agonists) reduces acute pain through activation of descending spinal serotonin pathways and subsequent activation of 5-HT2A and 5-HT7 receptors in the spinal cord. CBD interacts with pain receptors in the brain to exert pain-relieving and anti-inflammatory effects. A study on patients having neuropathic pain concluded that higher concentration of THC helps in alleviating pain (2).

Mood: A study conducted on 42 participants found that in comparison to placebo, when treated with low dose THC, subject showed significant reduction in both subjective distress and psychosocial stress and improved mood (3).

Depression: Serotonin, produced in brain from neurons, is important for regulating pain, mood, cognition, anxiety & depression. THC inhibits both serotonin-metabolizing MAO(Monoamine oxidase A) activity and serotonin reuptake activity and thus blocks the signal for depression (4).

Quality of life: It is found that cannabis use for cancer pain led to a 64-percent reduction in opioid use, improved quality of life, and caused fewer medication side effects. It also led to participants using fewer medications (5).

MECHANISM OF ACTION

Endocannabinoid system is a collection of neuromodulators (endocannabinoids), their receptors (CB1 & CB2) and signaling pathways in our body. It regulates the body’s physiological system to maintain homeostasis (the state of balance). Phyto-cannabinoids (CBD & THC) bind mainly to CB1 and CB2 receptors and specific enzymes &metabolites to activate the pathways and regulate the symptoms.

This is made using full-spectrum cannabis extract infused in coconut oil. The high grade organic coconut oil boosts the absorption of cannabinoids because it allows easy absorption in the digestive tract and metabolism in liver. Infusion of cannabinoids in coconut oil thus boosts the bioavailability of cannabinoids and helps in breaking down the cannabinoid-coconut oil complex in liver for immediate effect.

REFERENCE

Fawaz A.et al., Neuroinflammatory cytokines induce amyloid beta neurotoxicity through modulating amyloid precursor protein levels/metabolism. BioMed Research International, 2018, vol. 2018, Article ID 3087475, 8 pages. https://doi.org/10.1155/2018/3087475.
Ware MA. et. al., Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ, 2010,182(14):E694-701.
Childs E. et al. Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. Drug Alcohol Depend, 2017, 30: 177:136-144.
Velenovská M. & Fisar Z., Effect of cannabinoids on platelet serotonin uptake. Addict Biol., 2007, 12(2):158-166.
Boehnke, K.F. et al., Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain. The Journal of Pain,2016, 17(6):739-744.

MADE WITH

HPMC veg capsule filled with 250mg Cannabis leaves wholesome extract and organic cold pressed coconut oil.

SIDE EFFECTS & SAFETY

Cannaron+^® is LIKELY SAFE when taken orally as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in blood pressure, increased heartbeat, light-headedness, and drowsiness.

PRECAUTIONS & WARNING

Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug.

Pregnancy: Breast feeding mothers and pregnant women should take Cannaron+^® strictly under Doctor's supervision and guidance.

Heart disease: It might increase heartbeat, and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict Doctor’s guidance and supervision.

Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at least 2 weeks before a scheduled surgery.

Keep away from Children.

DO NOT drive or operate any machine while under Cannabis medication.

DO NOT take Alcohol while under Cannabis medication.

DRUG INTERACTION

Taking Cannaron+^® is LIKELY SAFE and can be taken with most drugs.However, it is best to consult your doctor before starting and sharing the list of all medications to find out drug interactions.

Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannaron+^® along with sedative medications might cause too much sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery and excited. Doctors call this hypomania.

Drugs for Alcohol de-addiction: Taking Cannaron+^® along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and irritability.

Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with drugs that control blood sugar level.

This drug can also interact with Astemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannaron+^® with these drug combinations.

DOSAGE

It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person depending on a person’s tolerance level. It is best to follow a physician’s advice to find the right dose.

No specific dose limit has been defined yet. However, mild adverse effects may occur in some at dosage > ~20mg THC, including nausea, postural hypotension, delirium, panic attacks, anxiety, and myoclonic jerking. In case of overdose, get medical help immediately.

Frequently asked questions about cannabis Medicines / Hemp Medicines

Question: what is cannabis medicines?

Answer: Medicinal Cannabis means the cannabis plant or its extract or chemical is used for medicinal purpose for treating several diseases. The Cannabis plant contains more than 100 different chemicals called phyto-cannabinoids. All Phytocannabinoids have different medicinal effects on bdy. However Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main chemicals which are highly potential in treating diseases.

Question: What is Cannabinoids?

Answer: Cannabinoids are the active constituents in cannabis plant and are similar to chemicals the body makes (called endocannabinoids) that are involved in appetite, memory, mood, movement and pain.

Question: What medicine contains cannabinoids?

Answer: Cannabinoids are the active constituents present in cannabis plant. Medicines like Cannapain and Cannaflam are made up of Cannabis leaf extract which contains cannabinoids.

Question: Who can take cannabis oil or Cannabis oil capsules?

Answer: Anyone above age 18+ can take these medicines but strictly under the Doctor’s supervision.

Question: Side effect of cannabis medicines, cannabis capsules, cannabis pills, cannabis oil capsules and cannabis oil?

Answer: Cannabis oil is generally well tolerated and considered safe to consume. However some common and mild side effects occur such as drowsiness, gastrointestinal issues, dry mouth and the event of occurrences of side effects are very rare.

Question: Is cannabis medicines or Cannabis medicine oil available in India?

Answer: Cannabis medicines in India is now gaining popularity because of its effectiveness. HempCann Solutions manufactures Ayurvedic cannabis medicines in India.

Cannabis Infused Products- : Ayurvedic classical and proprietary medicines such as Kameswar Modaka, Jatiphaladi churna, Bilvadi Churna, Sarpagandha ghanvati, Cannaflam, Cannapain etc are mainly cannabis infused products, where Cannabis leaves is one of the major ingredients.

Buy hemp Products – : Hemp products such hemp seeds, hemp seed oil, etc. are available in India on various online platform. Hemp medicines manufactured by Hempcann Solutions are available online at Vedi.

Buy Cannabis Products – Medical Cannabis Products such as Sarpagandha ghanvati, Kameswar modaka, Jatiphaladi, Bilvadi and proprietary cannabis medicines such as Cannapain and Cannaflam are manufactured by Hempcann solutions and are available online at Vedi.

Medical Marijuana Products in India – : In India marijuana Is basically used as medicine as processed bhang and bhang containing ayurvedic medicines. According to ayurveda, Bhang is used in more than 200 formulations for treating Various Diseases.

CANNARON+®